HIV TAT Peptide Modifies the Distribution of DNA Nanolipoparticles Following Convection-enhanced Delivery
نویسندگان
چکیده
منابع مشابه
Therapeutic applications of the cell-penetrating HIV-1 Tat peptide.
Over the past decades, many new therapeutic approaches have been developed for several conditions, including neurodegenerative diseases. However, efficient biodistribution and delivery at biological target sites are hampered by the presence of cell and tissue barriers, and a clinical therapy is prevented by the requirement of invasive administration routes. Candidate drug conjugation to cell-pe...
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Intracellular delivery of drugs and DNA is hampered by the cytotoxicity of some carrier systems (such as cationic lipids) and degradation of drugs or DNA as a results of endocytic processing. It has been shown that the coupling of HIV-1 TAT protein, or shorter TAT peptides derived from this protein, to other proteins and small colloidal particles facilitates their efficient intracellular delive...
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In spite of aggressive multi-modality treatments, patients diagnosed with anaplastic astrocytoma and glioblastoma continue to display poor median survival. The success of our current conventional and targeted chemotherapies are largely hindered by systemic- and neurotoxicity, as well as poor central nervous system (CNS) penetration. Interstitial drug administration via convection-enhanced deliv...
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BACKGROUND Intraparenchymal convection-enhanced delivery (CED) of therapeutics directly into the brain has long been endorsed as a medium through which meaningful concentrations of drug can be administered to patients, bypassing the blood brain barrier. The translation of the technology to clinic has been hindered by poor distribution not previously observed in smaller pre-clinical models. In p...
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ژورنال
عنوان ژورنال: Molecular Therapy
سال: 2008
ISSN: 1525-0016
DOI: 10.1038/mt.2008.36